Pyroglutamate is the basic form of pyroglumatic acid and it can be found in small portions in the body. It is considered to be an uncommon amino acid derivative and it especially serves an important role in the nervous system, specifically in the proper functioning of the brain.

Since pyroglutamate is predominantly found in the brain, it has the capacity to pass through blood and brain barriers thus enabling it to reside in the cerebrospinal fluid and the blood.

Other names for pyroglutamate include: Adjuvant, acid lactam, Alpha-aminoglutaric, Amino Mass, arginine pyroglutamate, Arginine Pidolate, Deep Thought, glutimic acid, glutamic acid lactam, glutiminic acid, Mental Edge, PCA, Piraglutargine, pyroGlu, pyroglutamic acid, pyrrolidon carboxylic acid, 2-oxo-pyrrolidon carboxylic acid.

There are several benefits that can be derived from pyroglutamate. It is known to improve the capacity of the brain to retain information and is thus helpful in maintaining a sharp memory. It also increases alertness and learning capacity. Another benefit from pyroglutamate is that it increases the ability of a person to concentrate and is effective in reducing anxiety and depression.

Pyroglutamate can be naturally derived from fruits, as well as dairy and meat products. The presence of pyroglutamate in these food products increases nitric oxide production which enhances blood flow and therefore causes a better delivery of nutrients and oxygen to the muscles. With this, a potent neurotransmitter is increased which is closely associated with the memory.

When arginine binds with pyroglutamate, arginine pyroglutamate is formed. With the presence of arginine, natural growth hormone is stimulated. This is one of the fastest and safest ways to enhance growth as a replacement to highly effective growth enhancement treatments. Arginine promotes protein synthesis, in return causing a speed and increase in muscle growth.

In 1981, arginine pyroglutamate was put on the spotlight by Italian researcher A. Isidori M.D., and some of his colleagues in the University of Rome. In a study that was conducted, arginine pyroglutamate combined with lysine was found ten folds more effective in increasing levels of human growth hormones.

These are the most common effects of arginine pyroglutamate:
• Improves the brain’s cognitive function
• Improves sexual functions
• Improves circulatory system
• Improves blood flow
• Improves protein synthesis

Working per se, Pyroglutamate has been found effective in increasing memory levels on alcohol-induced memory deficits among humans. Recently it has also been found helpful in decreasing states of dementia. Pyroglutamate significantly increased attention span and psychological performances among patients tested.

Indeed, pyroglutamate proves to be beneficial in improving memory skills and treating moderate cases to severe cases of memory loss and dementia.